Visceral adipose tissue area is an independent risk factor for hepatic steatosis
Article first published online: 7 NOV 2007
© 2007 The Authors. Journal compilation © 2007 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd
Journal of Gastroenterology and Hepatology
Volume 23, Issue 6, pages 900–907, June 2008
How to Cite
Park, B. J., Kim, Y. J., Kim, D. H., Kim, W., Jung, Y. J., Yoon, J. H., Kim, C. Y., Cho, Y. M., Kim, S. H., Lee, K. B., Jang, J. J. and Lee, H. S. (2008), Visceral adipose tissue area is an independent risk factor for hepatic steatosis. Journal of Gastroenterology and Hepatology, 23: 900–907. doi: 10.1111/j.1440-1746.2007.05212.x
- Issue published online: 7 NOV 2007
- Article first published online: 7 NOV 2007
- Accepted for publication 11 June 2007.
- metabolic syndrome;
- non-alcoholic fatty liver disease;
- visceral adipose tissue
Background and Aim: Recent data indicate that hepatic steatosis is associated with insulin resistance, dyslipidemia and obesity (especially central body fat distribution). There have been few studies on the correlation between biopsy-proven hepatic steatosis and the above factors in a disease-free population. The aim of the present study was to evaluate the relation between hepatic steatosis assessed by biopsy and clinical characteristics including regional fat distribution measured by computed tomography (CT) in living liver donors.
Methods: Laboratory data, liver/spleen Hounsfield ratio (L/S ratio), regional fat distribution by CT and liver status by biopsy were evaluated retrospectively in a total of 177 living liver donors without a history of alcohol intake.
Results: The unpaired t-test showed that age, triglycerides (TG), high density lipoprotein, total cholesterol, alanine aminotransferase, body mass index, L/S ratio, visceral adipose tissue area (VAT) and subcutaneous adipose tissue area (SAT) were associated with hepatic steatosis. In the multiple logistic regression analysis, VAT (odds ratio 1.031, 95% CI 1.013–1.048, P < 0.01) and TG (odds ratio 1.012, 95% CI 1.004–1.020, P < 0.01) were independent risk factors of hepatic steatosis. Subgroup analysis also showed that VAT was an independent risk factor in men (odds ratio 1.022, 95% CI 1.003–1.041, P < 0.05) and women (odds ratio 1.086, 95% CI 1.010–1.168, P < 0.05).
Conclusion: Our results suggest that visceral abdominal adiposity is correlated with hepatic steatosis in healthy living liver donors.