Role and significance of focal adhesion proteins in hepatocellular carcinoma
Article first published online: 30 MAR 2009
© 2009 The Authors. Journal compilation © 2009 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd
Journal of Gastroenterology and Hepatology
Volume 24, Issue 4, pages 520–530, April 2009
How to Cite
Yam, J. W. P., Tse, E. Y. T. and Ng, I. O.-L. (2009), Role and significance of focal adhesion proteins in hepatocellular carcinoma. Journal of Gastroenterology and Hepatology, 24: 520–530. doi: 10.1111/j.1440-1746.2009.05813.x
- Issue published online: 30 MAR 2009
- Article first published online: 30 MAR 2009
- Accepted for publication 21 January 2009.
- clinicopathological significance;
- focal adhesion proteins;
- hepatocellular carcinoma;
- signaling pathways
Focal adhesions are structural links between the extracellular matrix and actin cytoskeleton. They are important sites where dynamic alterations of proteins in the focal contacts are involved during cell movement. Focal adhesions are composed of diverse molecules, for instance, receptors, structural proteins, adaptors, GTPase, kinases and phosphatases. These molecules play critical roles in normal physiological events such as cellular adhesion, movement, cytoskeletal structure and intracellular signaling pathways. In cancers, aberrant expression and altered functions of focal adhesion proteins contribute to adverse tumor behavior. It is evident that these proteins do not function alone, but rather associate and work together in the process of tumor development and cancer metastasis. Focal adhesion proteins have been shown to play critical roles in hepatocellular carcinoma. Understanding the molecular interactions and mechanisms of the interconnected focal adhesion proteins is of particular importance in understanding mechanisms underlying hepatocellular carcinoma progression and development of potential effective treatment.