Effects of muscarinic receptor stimulation and nitric oxide synthase inhibition on gastric tone and gastric myoelectrical activity in canines

  1. Jihong Chen1,
  2. Jinhong Xing2,
  3. Jiande DZ Chen1,2,*

Article first published online: 13 APR 2009

DOI: 10.1111/j.1440-1746.2009.05843.x

Issue

Journal of Gastroenterology and Hepatology

Journal of Gastroenterology and Hepatology

Volume 24, Issue 6, pages 1130–1135, June 2009

Additional Information

How to Cite

Chen, J., Xing, J. and Chen, J. D. (2009), Effects of muscarinic receptor stimulation and nitric oxide synthase inhibition on gastric tone and gastric myoelectrical activity in canines. Journal of Gastroenterology and Hepatology, 24: 1130–1135. doi: 10.1111/j.1440-1746.2009.05843.x

Author Information

  1. 1

    Division of Gastroenterology, University of Texas Medical Branch, Galveston, Texas, and

  2. 2

    Veterans Research and Education Foundation, VA Medical Center, Oklahoma City, Oklahoma, USA

*Jiande Chen, GI Research, Route 0632, 1108 The Strand, room 221, University of Texas Medical Branch, Galveston, TX 77555-0632, USA. Email: jianchen@utmb.edu

Publication History

  1. Issue published online: 27 MAY 2009
  2. Article first published online: 13 APR 2009
  3. Accepted for publication 16 December 2008.

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Keywords:

  • cholinergic pathway;
  • gastric fundic tone;
  • gastric myoelectrical activity;
  • gastric slow wave;
  • nitrergic pathway

Abstract

Aims:  This study was designed to assess whether the muscarinic receptor stimulation and nitric oxide synthase inhibition were equally effective on gastric fundic tone or gastric myoelectrical activity (GMA) in canines, and the correlation between gastric fundic tone and GMA.

Methods:  Gastric fundic tone and GMA were recorded on seven dogs implanted with serosal electrodes and a gastric cannula.

Results:  Bethanechol and L-nitro-N-arginine (L-NNA) significantly increased gastric fundic tone; gastric volume was decreased with bethanechol or L-NNA (P < 0.05). Increased spike activities were observed after both bethanechol and L-NNA. The percentage of slow waves superimposed with spikes was increased with bethanechol (P < 0.001) and L-NNA (P < 0.05). There was a significant reduction in dominant frequency (DF) (P < 0.05), dominant power (DP) (P < 0.05) and percentage of normal slow waves (%N) (P < 0.05) with bethanechol, while no significant change was observed with L-NNA. The variation of gastric tone was not correlated with parameters of GMA.

Conclusions:  Muscarinic receptor stimulation and nitric oxide synthase inhibition have similar effects on gastric tone and gastric spike activities, but different effects on gastric slow waves. Gastric fundic tone does not correlate with gastric slow waves.

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