Performance of acidified 14C-urea capsule breath test during pantoprazole and ranitidine treatment
Article first published online: 13 APR 2009
© 2009 The Authors. Journal compilation © 2009 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd
Journal of Gastroenterology and Hepatology
Volume 24, Issue 7, pages 1248–1251, July 2009
How to Cite
Öztürk, E., Yeşilova, Z., Ilgan, S., Özgüven, M. and Dağalp, K. (2009), Performance of acidified 14C-urea capsule breath test during pantoprazole and ranitidine treatment. Journal of Gastroenterology and Hepatology, 24: 1248–1251. doi: 10.1111/j.1440-1746.2009.05845.x
- Issue published online: 29 JUL 2009
- Article first published online: 13 APR 2009
- Accepted for publication 28 January 2009.
- citric acid;
- helicobacter pylori;
- urea breath test
Background and Aim: Urea breath test (UBT) results could be false negative in patients taking antisecretory drugs. This effect would be prevented by citric acid administration during UBT. We prospectively investigated whether acidified 14C-urea capsule prevents false negative UBT results in patients taking antisecretory drugs and show interference with the duration of medications.
Methods: Sixty Helicobacter pylori positive patients were included. Pantoprazole (40 mg/day) was given to 27 patients for 28 days and ranitidine (300 mg. o.d.) to 33 patients for 60 days. Urea breath tests were repeated on days 14 and 28 in both groups and on day 60 in the ranitidine group.
Results: The baseline mean breath counts of two groups did not show any significant difference. Pantoprazole led to a significant decrease in mean breath counts on day 14 (P < 0.005). Six of 27 and 3 of 25 patients taking pantoprazole developed negative or equivocal UBT results on days 14 and 28, respectively. Two of 32, 2 of 32 and 3 of 21 patients taking ranitidine developed negative or equivocal UBT results on days 14, 28 and 60, respectively.
Conclusions: The use of acidified 14C-urea capsule did not prevent false negative UBT results in patients taking pantoprazole and ranitidine, and the duration of medication does not affect the test results.