Effects of mosapride on esophageal functions and gastroesophageal reflux
Article first published online: 3 FEB 2010
© 2010 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd
Journal of Gastroenterology and Hepatology
Volume 25, Issue 6, pages 1066–1071, June 2010
How to Cite
Koshino, K., Adachi, K., Furuta, K., Ohara, S., Morita, T., Nakata, S., Tanimura, T., Miki, M. and Kinoshita, Y. (2010), Effects of mosapride on esophageal functions and gastroesophageal reflux. Journal of Gastroenterology and Hepatology, 25: 1066–1071. doi: 10.1111/j.1440-1746.2010.06280.x
- Issue published online: 26 MAY 2010
- Article first published online: 3 FEB 2010
- Accepted for publication 21 January 2010.
- esophageal peristaltic contraction;
- gastroesophageal reflux;
- impedance monitoring;
- lower esophageal sphincter;
Background and Aim: A substantial number of patients with gastroesophageal reflux disease show symptomatic resistance to high-dose proton pump inhibitors. In those cases, prokinetics are possible candidates for treatment. The aim of the present study was to determine whether mosapride, a prokinetic agent, stimulates esophageal functions, and prevents acidic and non-acidic gastroesophageal reflux.
Methods: Normal volunteers (nine and 13 for two experiments, respectively) were enrolled. Salivary secretion, esophageal peristaltic contractions, and resting lower esophageal sphincter pressure with and without mosapride administration were recorded using a cross-over protocol. Post-prandial acidic and non-acidic reflux levels were also recorded.
Results: Mosapride at a standard dose of 15 mg/day did not stimulate salivary secretion or any esophageal motor functions. It also failed to prevent acidic and non-acidic post-prandial gastroesophageal reflux.
Conclusions: Mosapride at 15 mg/day, a standard dose in Japan, did not change the esophageal motility and salivary secretion in healthy volunteers. Future study on a larger number of individuals with higher dose of mosapride is worthwhile.