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- Human liver cell transplanted uPA/scid mice
- Study of hepatitis B virus infection using human hepatocyte chimeric mice
- Study of hepatitis C virus using human hepatocyte chimeric mice
Human hepatitis B virus (HBV) and hepatitis C virus (HCV) infect only chimpanzees and humans. Analysis of both viruses has long been hampered by the absence of a small animal model. The recent development of human hepatocyte chimeric mice has enabled us to carry out studies on viral replication and cellular changes induced by replication of human hepatitis viruses. Various therapeutic agents have also been tested using this model. In the present review, we summarize published studies using chimeric mice and discuss the merits and shortcomings of this model.