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Clinical characteristics of TIMP2, MMP2, and MMP9 gene polymorphisms in colorectal cancer

Authors

  • Kyung Sook Park,

    Corresponding author
    1. Department of Biology, Sungshin Women's University, Seoul, Korea
      Dr Kyung Sook Park, School of Biological Science and Chemistry Department of Biology, Sungshin Women's University, 249-1, Dongseon-dong 3-ga, Sungbuk-ku, Seoul 136-742, Korea. Email: kspark@sungshin.ac.kr
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  • Seon Jeong Kim,

    1. Department of Biology, Sungshin Women's University, Seoul, Korea
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  • Kyung Ho Kim,

    1. Department of Surgery and Institute of Innovative Cancer Research, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea
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  • Jin Cheon Kim

    1. Department of Surgery and Institute of Innovative Cancer Research, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea
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Dr Kyung Sook Park, School of Biological Science and Chemistry Department of Biology, Sungshin Women's University, 249-1, Dongseon-dong 3-ga, Sungbuk-ku, Seoul 136-742, Korea. Email: kspark@sungshin.ac.kr

Abstract

Background and Aim:  Genetic variations and the expression profile of matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMP) are involved in the invasion and metastasis of colorectal cancer.

Methods:  The gene profiles of TIMP2 and MMP were assayed from 333 colorectal cancer using polymerase chain reaction–restriction fragment length polymorphism.

Results: TIMP2-418*G/*G, TIMP2 303*G/*G and MMP9-1562*C/*C were more frequent in patients than in controls (P = 0.020, P < 0.0001 and P < 0.044, respectively). Frequency of TIMP2-418*G/*G was higher in patients with metastasis than in those without metastasis, and that of TIMP2 303*G/*G was higher in patients with rectal cancer than in those with colon cancer (P = 0.008 and P = 0.022, respectively). TIMP2-303*A/*A and MMP2-1575*G/*G were less frequent in patients than in controls (P = 0.001 and P = 0.005, respectively). The TIMP2-418*G303*G haplotype was more frequent (P < 0.0001) and MMP2-1575*G-735*C haplotype was less frequent in patients than in controls (P = 0.005).

Conclusion:  Specific single-nucleotide polymorphism in TIMP2 and MMP appeared to be associated with tumorigenesis and biological behavior in colorectal cancer, which is expected be further verified in a larger cohort in the future.

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