Financial disclosure: The authors have no financial disclosure to make.
Prevalence and clinical profile of celiac disease in type 1 diabetes mellitus in north India
Version of Record online: 25 JAN 2011
© 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd
Journal of Gastroenterology and Hepatology
Volume 26, Issue 2, pages 378–381, February 2011
How to Cite
Bhadada, S. K., Kochhar, R., Bhansali, A., Dutta, U., Kumar, P. R., Poornachandra, K. S., Vaiphei, K., Nain, C. K. and Singh, K. (2011), Prevalence and clinical profile of celiac disease in type 1 diabetes mellitus in north India. Journal of Gastroenterology and Hepatology, 26: 378–381. doi: 10.1111/j.1440-1746.2010.06508.x
- Issue online: 25 JAN 2011
- Version of Record online: 25 JAN 2011
- Accepted manuscript online: 28 SEP 2010 06:36PM EST
- Accepted for publication 21 May 2010.
- celiac disease;
- diabetes mellitus;
- short stature
Background and Aim: There is scanty data on the occurrence of celiac disease in patients with type 1 diabetes mellitus in South Asia. Our aim was to study the prevalence and clinical profile of celiac disease in patients with type 1 diabetes mellitus in a tertiary care referral centre in north India.
Methods: Consecutive patients of type 1 diabetes mellitus attending the Endocrine clinic of our institute between January 2002 and December 2008 were screened using anti-tissue transglutaminase antibodies (tTGAb), and those positive were subjected to duodenal biopsy. Clinical profile of these patients was recorded.
Results: Out of 189 patients of type 1 diabetes mellitus, 21 (11.1%) were diagnosed to have celiac disease on the basis of positive serology (tTGAb) and duodenal histology. The mean age at diagnosis of diabetes was 10.81 ± 7.3 years and that of celiac disease was 13.74 ± 5.71 years, with a difference of 5.18 ± 4.75 years between the two. Only 2/21 patients with celiac disease had been diagnosed before detection of diabetes mellitus. Short stature was the commonest (52.3%) manifestation of celiac disease, followed by anemia (47.3), weight loss (42.8%), diarrhea (28.6%) and abdominal pain (14.2%). After initiating gluten free diet, 14/16 symptomatic patients had reversal of anemia, weight loss and diarrhea. Growth rate velocity improved from 2.3 ± 1.0 cm/year to 5.5 ± 2.4 cm/year in those with short stature.
Conclusion: Celiac disease is highly prevalent in patients with type 1 diabetes mellitus (11.1%) and majority of them (90.5%) were diagnosed on screening. Routine screening is required for early diagnosis and combat associated co-morbidities.