Conflict of interest
Small intestinal bacterial overgrowth (SIBO) in irritable bowel syndrome: Frequency and predictors
Article first published online: 28 MAR 2011
© 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd
Journal of Gastroenterology and Hepatology
Special Issue: Proceedings of the first Asian Pacific Topic Conference (APTC2010) on Functional Gastrointestinal Disorders Organized by the Japanese Society of Gastroenterology (JSGE)and Asian Pacific Association of Gastroenterology (APAGE), Tokyo, Japan, 26-27 November 2010
Volume 26, Issue Supplement s3, pages 135–138, April 2011
How to Cite
Sachdeva, S., Rawat, A. K., Reddy, R. S. and Puri, A. S. (2011), Small intestinal bacterial overgrowth (SIBO) in irritable bowel syndrome: Frequency and predictors. Journal of Gastroenterology and Hepatology, 26: 135–138. doi: 10.1111/j.1440-1746.2011.06654.x
No potential conflict of interest to disclose.
- Issue published online: 28 MAR 2011
- Article first published online: 28 MAR 2011
- Accepted for publication 24 January 2011.
Objective and Background: Small intestinal bacterial overgrowth (SIBO) has been implicated in pathogenesis of IBS. We aimed to study frequency and predictors of SIBO in patients with IBS.
Methodology: We included 59 consecutive patients of IBS & 37 healthy controls (HC). Evaluation for SIBO was done by glucose breath test (GBT) using 100 gm of glucose after an overnight fast. Breath hydrogen & methane concentration were noted at baseline & every 15 min after administration of glucose for a total of 3 h. Persistent rise in breath hydrogen or methane > 12 ppm above basal was considered diagnostic of SIBO.
Results: Of 59 patients, 27 were diarrhoea predominant (D-IBS), 11 were constipation predominant (C-IBS) and 21 were mixed type (M-IBS). Median age of patients (34 [18–47] years) were comparable to controls (35 [20–48] years) (P = 0.21). Patient group was similar to HC in gender distribution (male 41/59 [69.5%]vs 25/37 [67.6%], P = 0.36). SIBO was more frequent in patients with IBS than HC (14/59 [23.7%]vs 1/37 [2.7%], P = 0.008). Patients with D-IBS more often had SIBO as compared to non-D-IBS (10/27 [37%]vs 4/32 [12.5%], P = 0.02). C-IBS had lowest frequency of SIBO (1/11 [9%]) among all IBS subgroups. Patients with history of bloating more often had SIBO as compared to those without this symptom (11/23 [47.8%]vs 3/36 [8.3%], P = 0.002). Among IBS patients, females more often had SIBO as compared to males (8/18 [44.4%]vs 6/41 [14.6%], P = 0.01).
Conclusions: SIBO was more frequent in patients with IBS as compared to healthy controls. D-IBS subtype, female gender & bloating were predictors of SIBO in patients with IBS.