Prediction of improved liver function after balloon-occluded retrograde transvenous obliteration: Relation to hepatic vein pressure gradient
Article first published online: 21 DEC 2011
© 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd
Journal of Gastroenterology and Hepatology
Volume 27, Issue 1, pages 137–141, January 2012
How to Cite
Uehara, H., Akahoshi, T., Tomikawa, M., Kinjo, N., Hashimoto, N., Nagao, Y., Kamori, M. and Maehara, Y. (2012), Prediction of improved liver function after balloon-occluded retrograde transvenous obliteration: Relation to hepatic vein pressure gradient. Journal of Gastroenterology and Hepatology, 27: 137–141. doi: 10.1111/j.1440-1746.2011.06835.x
- Issue published online: 21 DEC 2011
- Article first published online: 21 DEC 2011
- Accepted manuscript online: 1 JUL 2011 07:00AM EST
- Accepted for publication 8 June 2011.
- balloon-occluded transvenous obliteration;
- hepatic venous pressure gradient;
- liver function
Background and Aims: Balloon-occluded retrograde transvenous obliteration (B-RTO) is an effective treatment for gastric varices (GVx), as well as hepatic encephalopathy. The aim of this study was to examine the changes of the hepatic vein pressure gradient (HVPG) after B-RTO and determine the relation between the changes of HVPG and liver function.
Patients and Methods: B-RTO was performed in 30 patients with GVx and hepatic encephalopathy. HVPG was measured in 19 of 30 patients both before and after B-RTO.
Results: The B-RTO was successful in all patients. The GVx and hepatic encephalopathy were improved, and no recurrence or bleeding was observed within the follow- up period. The serum albumin and prothrombin activity were significantly improved 6 months after B-RTO in all patients. HVPG was elevated 44% above the baseline after B-RTO. Liver function significantly improved 6 months after B-RTO in patients whose HVPG increased ≥ 20% from baseline.
Conclusion: An elevated HVPG after B-RTO is one aspect of the effect of liver function, and an HVPG increase of ≥ 20% from baseline is a predictive factor for obtaining an improvement of liver function.