Conflicts of Interest: None of the authors has a conflict of interest.
Acute-on-chronic liver failure in chronic hepatitis B
Article first published online: 22 MAR 2012
© 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd
Journal of Gastroenterology and Hepatology
Volume 27, Issue 4, pages 662–669, April 2012
How to Cite
Seto, W.-K., Lai, C.-L. and Yuen, M.-F. (2012), Acute-on-chronic liver failure in chronic hepatitis B. Journal of Gastroenterology and Hepatology, 27: 662–669. doi: 10.1111/j.1440-1746.2011.06971.x
Role of the funding source: None of the authors has anything to disclose.
The authors declare they have participated in the preparation of the manuscript and have seen and approved the final version.
- Issue published online: 22 MAR 2012
- Article first published online: 22 MAR 2012
- Accepted manuscript online: 18 NOV 2011 01:50PM EST
- Accepted for publication 29 September 2011.
- acute-on-chronic liver failure;
- hepatitis B;
- hepatitis B virus DNA;
- liver failure;
- Model of End-stage Liver Disease;
Acute-on-chronic liver failure (ACLF) in chronic hepatitis B (CHB) is most commonly caused by acute severe exacerbation of CHB. The pathophysiology of ACLF in CHB is still poorly understood. Despite the identification of important predisposing factors and prognostic markers, ACLF in CHB remains a disease associated with high mortality. The majority of studies using nucleoside analog therapy did not show any significant improvement in survival, although larger prospective studies are needed. Liver transplantation is the definitive treatment for ACLF in CHB. The challenge ahead would be prognosticating cases with favorable or unfavorable outcomes in order to streamline patients for early transplantation or for medical therapy.