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Relationship of interleukin-1β levels and gastroesophageal reflux disease in Korea

Authors

  • Jin Joo Kim,

    1. Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
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  • Nayoung Kim,

    Corresponding author
    1. Department of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, Gyeonggi-do, Korea
    • Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
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  • Sungwook Hwang,

    1. Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
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  • Jae Yeon Kim,

    1. Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
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  • Ji Yeon Kim,

    1. Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
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  • Yoon Jin Choi,

    1. Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
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  • Dong Ho Lee,

    1. Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    2. Department of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, Gyeonggi-do, Korea
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  • Hyun Chae Jung

    1. Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
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Correspondence

Dr Nayoung Kim, Department of Internal Medicine, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam, Gyeonggi-do 463-707, South Korea. Email: nayoungkim49@empal.com

Abstract

Background and Aim

Gastric mucosal expression of interleukin (IL)-1β may alter acid secretion and influence the development of gastroesophageal reflux disease (GERD). The relationship of gastric mucosal IL-1β level and GERD was evaluated in the Korean population.

Methods

Genotypes of IL-1B-511 and IL-1RN VNTR polymorphism and clinical characteristics were analyzed in 44 patients with erosive esophagitis (EE), 32 patients with minimal change lesions (MCL), 54 patients with non-erosive reflux disease (NERD) and 113 controls. Gastric mucosal IL-1β levels were measured by enzyme linked immunosorbent assay.

Results

Significant differences were found between the EE and the control group with respect to sex, body mass index, and Helicobacter pylori infection. On the other hand, the MCL and the NERD group showed similar characteristics to that of the control group. IL-1B-511 genetic polymorphism showed relationship with gastric mucosal IL-1β levels. That is, T/T group (112.4 ± 14.3 pg/mg) had higher IL-1β level than C/C group (59.5 ± 11.6, P = 0.011). T carriers (92.8 ± 7.6 pg/mg) showed higher level than T non-carrier group (P = 0.050). In addition, mucosal IL-1β level of the EE group (52.3 ± 9.9 pg/mg) was lower than that of the control (107.8 ± 12.6 pg/mg, P = 0.001), the MCL (103.1 ± 13.5 pg/mg, P = 0.004), and the NERD group (83.8 ± 14.5 pg/mg, P = 0.079). However, genetic polymorphisms of IL-1B-511 and IL-1RN VNTR did not reach statistical significance among four groups.

Conclusion

Gastric mucosal IL-1β level might be one factor in the development of GERD.

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