Financial disclosures: None.
Comparison of clinical characteristics of combined hepatocellular-cholangiocarcinoma and other primary liver cancers
Article first published online: 19 DEC 2012
© 2012 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd
Journal of Gastroenterology and Hepatology
Volume 28, Issue 1, pages 122–127, January 2013
How to Cite
Lee, C.-H., Hsieh, S.-Y., Chang, C.-J. and Lin, Y.-J. (2013), Comparison of clinical characteristics of combined hepatocellular-cholangiocarcinoma and other primary liver cancers. Journal of Gastroenterology and Hepatology, 28: 122–127. doi: 10.1111/j.1440-1746.2012.07289.x
- Issue published online: 19 DEC 2012
- Article first published online: 19 DEC 2012
- Accepted manuscript online: 4 OCT 2012 06:29AM EST
- Manuscript Accepted: 26 JUL 2012
- combined hepatocellular-cholangiocarcinoma;
- hepatitis B;
- hepatitis C
Background and Aim
Combined hepatocellular-cholangiocarcinoma (CHC) is a rare liver malignancy. In this study, we compared patient characteristics and outcomes for primary CHC, intrahepatic cholangiocarcinoma (ICC), and hepatocellular carcinoma (HCC).
Medical records of patients with tissue-proven CHC (65 cases) treated at the Chang Gung Memorial Hospital between 1991 and 2005 were retrospectively reviewed. These records were compared to records of patients diagnosed with tissue-proven HCC (1985 cases) and ICC (127 cases) during the same period.
Hepatitis B and C are major causes of CHC. CHC patients exhibited greater similarity to HCC than to ICC patients with respect to cirrhotic changes, age, and positive serology for hepatitis B surface antigen and anti-hepatitis C antibody. Survival was related to tumor characteristics and intervention therapies, but not to etiologies.
The clinical characteristics of CHC are similar to those of HCC, but overall survival is more similar to that of ICC; survival may be related to tumor biology rather than the cause. Multimodal treatment with an initial aggressive therapeutic approach can improve survival.