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SYNOPSIS

The simian crease is a familiar feature of Down's syndrome. Less well known is the extended proximal transverse palmar crease (‘the Sydney line’). A study of the incidence of unusual palmar creases in 105 patients with a clinical diagnosis of Down's syndrome has shown a statistically significant increase in the incidence of both the simian and Sydney lines in these patients. The total incidence of unusual palmar creases in Down's syndrome is thus higher than it was previously thought to be.