Cyclic bisphosphonate therapy in osteogenesis imperfecta type V

Authors


Professor David O. Sillence, Academic Department of Medical Genetics, The Children's Hospital at Westmead, Sydney, NSW 2145, Australia. Fax: + 61 02 9845 3204; email: davids@chw.edu.au

Abstract

Abstract:  The clinical and radiographic features and management of a young person with recently delineated Osteogenesis Imperfecta Type V is described. A female aged 9 years presented with a history of multiple fractures since 3 years of age and bilateral dislocation of the elbows from infancy. She was commenced on a low dose frequent regimen of cyclic intravenous pamidronate, which resulted in progressive improvement in bone density, reduced fracture frequency and remission of symptoms of osteoporosis.

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