How to use medicines in children: Principles of paediatric clinical pharmacology
Article first published online: 16 FEB 2007
Journal of Paediatrics and Child Health
Volume 43, Issue 3, pages 107–111, March 2007
How to Cite
Sinha, Y. and Cranswick, N. E. (2007), How to use medicines in children: Principles of paediatric clinical pharmacology. Journal of Paediatrics and Child Health, 43: 107–111. doi: 10.1111/j.1440-1754.2007.00970.x
- Issue published online: 16 FEB 2007
- Article first published online: 16 FEB 2007
- Accepted for publication 30 July 2006.
- clinical trials;
- off-label prescribing
Abstract: Knowledge of drug administration in children and infants has significantly lagged behind that of adults. Despite several paediatric therapeutic mishaps that have been a catalyst for major regulatory reform, the majority of registered medicines do not have indications or dosing for children. This paper will briefly summarise key issues in paediatric pharmacology, including differences in prescribing for children, off-label and unlicensed prescribing and conduct of paediatric clinical trials. A particular emphasis will placed on the situation in Australia.