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Encephalopathy after furosemide use in nephrotic syndrome

  1. Ajay P Sharma,
  2. Joanne Grimmer

Article first published online: 16 FEB 2007

DOI: 10.1111/j.1440-1754.2007.01042.x

Issue

Journal of Paediatrics and Child Health

Journal of Paediatrics and Child Health

Volume 43, Issue 3, pages 188–190, March 2007

Additional Information

How to Cite

Sharma, A. P. and Grimmer, J. (2007), Encephalopathy after furosemide use in nephrotic syndrome. Journal of Paediatrics and Child Health, 43: 188–190. doi: 10.1111/j.1440-1754.2007.01042.x

Author Information

  1. Department of Pediatrics, University of Western Ontario, London, Ontario, Canada

*Dr Ajay P Sharma, Pediatric Nephrology, 800, Commissioner’s Road E, Children’s Hospital of Western Ontario/London Health Sciences Centre, London, ON, Canada N6A 2V5. Fax: 519-685-8156; email: ajay.sharma@lhsc.on.ca

Publication History

  1. Issue published online: 16 FEB 2007
  2. Article first published online: 16 FEB 2007
  3. Accepted for publication 24 October 2006.

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Keywords:

  • encephalopathy;
  • furosemide;
  • nephrotic syndrome;
  • respiratory failure

Abstract:  An 18-year-old girl with nephrotic syndrome presented with a life-threatening respiratory failure and a severe encephalopathy, shortly after being started on furosemide. The evaluation confirmed furosemide as the sole culprit for the clinical manifestations. This case highlights an unpredictable dose–response relationship of furosemide. The pathophysiological basis, differential diagnosis and clinical implications of the observed findings are discussed.

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