Group A streptococcal infections in children
Article first published online: 13 APR 2007
Journal of Paediatrics and Child Health
Volume 43, Issue 4, pages 203–213, April 2007
How to Cite
Steer, A. C., Danchin, M. H. and Carapetis, J. R. (2007), Group A streptococcal infections in children. Journal of Paediatrics and Child Health, 43: 203–213. doi: 10.1111/j.1440-1754.2007.01051.x
- Issue published online: 13 APR 2007
- Article first published online: 13 APR 2007
- Accepted for publication 19 April 2006.
- acute rheumatic fever;
- group A streptococcus;
- post-streptococcal glomerulonephritis
Abstract: The group A streptococcus causes the widest range of disease in humans of all bacterial pathogens. Group A streptococcal diseases are more common in children than adults with diseases ranging from pharyngitis and impetigo to invasive infections and the post-streptococcal sequelae – acute rheumatic fever and acute post-streptococcal glomerulonephritis. The global burden of severe group A streptococcal disease is concentrated largely in developing countries and Indigenous populations such as Aboriginal Australians. Control of group A streptococcal disease is poor in these settings and the need for a vaccine has been argued. With an ever-increasing understanding of the group A streptococcus at a molecular level, new and sophisticated vaccines are currently in human trials and the next decade holds exciting prospects for curbing group A streptococcal diseases.