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Early intervention for the ocular and neurodevelopmental sequelae of Fetal Valproate Syndrome


Dr Zia I Carrim, Department of Ophthalmology, Southern General Hospital, 1345 Govan Road, Glasgow G51 4TF, Scotland, UK. Fax: +44 141 201 413; email:


Abstract:  The established teratogenicity of antiepileptic drugs raises important issues in women of child-bearing age. While the association between neural tube defects and antiepileptic drugs is well recognised, other congenital malformations are known to occur. We report two siblings with characteristic craniofacial features of Fetal Valproate Syndrome who also had associated ocular and neurodevelopmental problems which would benefit from early recognition and intervention.

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