Octreotide in children with hypoglycaemia due to sulfonylurea ingestion

Authors

  • Shoshana Rath,

    1. Department of Paediatrics, Alice Springs Hospital and
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  • Naor Bar-Zeev,

    1. Department of Paediatrics, Alice Springs Hospital and
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  • Kym Anderson,

    1. Department of Paediatrics, Alice Springs Hospital and
    2. Flinders University Northern Territory Clinical School, Alice Springs Campus, Alice Springs, Northern Territory, Australia
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  • Rosemary Fahy,

    1. Department of Paediatrics, Alice Springs Hospital and
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  • Rob Roseby

    Corresponding author
    1. Department of Paediatrics, Alice Springs Hospital and
    2. Flinders University Northern Territory Clinical School, Alice Springs Campus, Alice Springs, Northern Territory, Australia
      Dr Rob Roseby, Department of Paediatrics, Alice Springs Hospital, PO Box 2234, Alice Springs, NT 0870, Australia. Fax: +61 8 8951 6976; email: rob.roseby@nt.gov.au
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Dr Rob Roseby, Department of Paediatrics, Alice Springs Hospital, PO Box 2234, Alice Springs, NT 0870, Australia. Fax: +61 8 8951 6976; email: rob.roseby@nt.gov.au

Abstract

Abstract:  Sulfonylureas are commonly prescribed for type 2 diabetes mellitus; however, overdose or accidental ingestion may result in profound and prolonged hypoglycaemia with permanent neurological sequelae and death. We describe two cases of children with hypoglycaemia due to presumed accidental ingestion of sulfonylureas, where traditional methods of raising blood sugar levels were unsatisfactory. Two studies describe Octreotide for adults with hypoglycaemia, but there are no studies examining the use of Octreotide in children for this indication. Given that Octreotide has been shown to be safe in children when used for other indications, we used Octreotide to safely restore euglycaemia.

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