Bone mass density and associated factors in cystic fibrosis patients of young age
Article first published online: 10 DEC 2008
© 2008 The Authors. Journal compilation © 2008 Paediatrics and Child Health Division (Royal Australasian College of Physicians)
Journal of Paediatrics and Child Health
Volume 44, Issue 12, pages 681–685, December 2008
How to Cite
Douros, K., Loukou, I., Nicolaidou, P., Tzonou, A. and Doudounakis, S. (2008), Bone mass density and associated factors in cystic fibrosis patients of young age. Journal of Paediatrics and Child Health, 44: 681–685. doi: 10.1111/j.1440-1754.2008.01406.x
- Issue published online: 18 DEC 2008
- Article first published online: 10 DEC 2008
- Accepted for publication 03 June 2008.
- cystic fibrosis;
- bone mineral density;
- vitamin D deficiency
Aim: To investigate bone mineral status in young cystic fibrosis (CF) patients and determine risk factors related with the development of low bone mineral density (BMD).
Methods: We determined, in 81 patients with CF, 4 to 23-years-old, BMD as well as factors, which are thought to play a role in the development of reduced BMD.
Results: BMD Z-score was between −1 and −2.5 in 27 (33%) and lower than −2.5 in 9 (11%). Means of BMD Z-score were lower than the expected value of 0 in the three groups of children, adolescents and young adults (P = 0.004; P < 0.001; P = 0.048, respectively), but they did not differ among them (P = 0.114). Analysis showed that Shwachman–Kulczycki (SK) score, gender and levels of 25-hydroxy-vitamin D were significant predictors of BMD Z-score. Significant also was the interaction between gender and SK score.
Conclusions: Our study supports that BMD may be reduced from a young age in CF patients though this needs to be confirmed using true volumetric measures of BMD. This defect is related to disease severity with males being more vulnerable. Inefficient levels of vitamin D are very common and contribute significantly to impaired bone health. The latter finding underlines the need for higher supplementation doses.