Profound encephalopathy with complete recovery in three children with familial hemiplegic migraine
Article first published online: 13 MAR 2009
© 2009 The Authors. Journal compilation © 2009 Paediatrics and Child Health Division (Royal Australasian College of Physicians)
Journal of Paediatrics and Child Health
Volume 45, Issue 3, pages 154–157, March 2009
How to Cite
Hart, A. R., Trinick, R., Connolly, D. J. and Mordekar, S. R. (2009), Profound encephalopathy with complete recovery in three children with familial hemiplegic migraine. Journal of Paediatrics and Child Health, 45: 154–157. doi: 10.1111/j.1440-1754.2009.01465.x
- Issue published online: 13 MAR 2009
- Article first published online: 13 MAR 2009
- Accepted for publication 12 July 2008.
- migraine with aura
We describe three cousins who presented with agitation, dysphasia and/or coma, and developed hemiplegia following initial onset of symptoms. Two cases followed minor head injuries, two were pyrexial and two were associated with neutrophilia. Two cases required ventilatory support on the intensive care unit. Magnetic resonance imaging in all three cases showed cortical swelling, and one had evidence of restricted water diffusion on diffusion-weighted imaging, suggestive of ischaemia/infarction. A complete family history at the time of presentation would have led to an earlier diagnosis of profound encephalopathy in familial hemiplegic migraine, which would have enabled better prognostication of their clinical course and caused less distress for the families.