Three siblings with self-resolving congenital hyperthyrotropinaemia secondary to thyrotropin receptor blocking antibodies
Article first published online: 16 FEB 2010
© 2010 The Authors. Journal compilation © 2010 Paediatrics and Child Health Division (Royal Australasian College of Physicians)
Journal of Paediatrics and Child Health
Volume 46, Issue 7-8, pages 439–441, July/August 2010
How to Cite
Azzopardi, P., Forrester, M. and Ehtisham, S. (2010), Three siblings with self-resolving congenital hyperthyrotropinaemia secondary to thyrotropin receptor blocking antibodies. Journal of Paediatrics and Child Health, 46: 439–441. doi: 10.1111/j.1440-1754.2009.01687.x
- Issue published online: 16 JUL 2010
- Article first published online: 16 FEB 2010
- Accepted for publication 9 June 2009.
- congenital hypothyroidism;
- thyrotropin receptor antibody;
- neonatal thyroid screening
Thyrotropin receptor blocking antibodies are a rare cause of hyperthyrotropinaemia and more rarely of congenital hypothyroidism. We report a case of hyperthyrotropinaemia but normal thyroid hormone in the newborn of a mother with hypothyroidism treated with thyroxine. Two older siblings had similar high thyrotropin and normal thyroid function in the newborn period which did not require hormone treatment and resolved spontaneously. Demonstration of thyrotropin receptor antibodies in the child confirmed our diagnosis. Our case was not treated with thyroid replacement hormone and has remained biochemically euthyroid, with thyrotropin levels returning to normal over a period of months.