Competing interest: The authors have no competing interests to report.
Chronic urticaria of neonatal onset: A potential sign of autoinflammation
Article first published online: 16 FEB 2010
© 2010 The Authors. Journal compilation © 2010 Paediatrics and Child Health Division (Royal Australasian College of Physicians)
Journal of Paediatrics and Child Health
Volume 46, Issue 10, pages 608–610, October 2010
How to Cite
Mehr, S., Jones, K. J., Singh-Grewal, D., Aksentijevich, I. and Kakakios, A. (2010), Chronic urticaria of neonatal onset: A potential sign of autoinflammation. Journal of Paediatrics and Child Health, 46: 608–610. doi: 10.1111/j.1440-1754.2009.01688.x
Funding: SM was partly supported by funds received from the Australian Allergy Foundation.
- Issue published online: 16 FEB 2010
- Article first published online: 16 FEB 2010
- Accepted for publication 2 July 2009.
- chronic infantile neurological;
- cutaneous and articular syndrome;
We present a 6 year old boy with chronic urticaria of neonatal onset associated in childhood with features of neurological and joint inflammation. Genetic analysis confirmed the diagnosis of neonatal onset multi-inflammatory disorder (NOMID). Daily subcutaneous anti-IL-1 receptor antagonist therapy resulted in a dramatic and sustained amelioration of systemic inflammation. NOMID must be considered in any child with chronic urticaria of neonatal/infantile onset, particularly if associated with joint and/or neurological inflammation.