Potential Conflict of Interest: RRD is a member of a pneumococcal vaccines advisory committee (Prevenar, Wyeth).
Streptococcus pneumoniae sepsis in the newborn
Article first published online: 29 DEC 2010
© 2010 The Authors. Journal of Paediatrics and Child Health © 2010 Paediatrics and Child Health Division (Royal Australasian College of Physicians)
Journal of Paediatrics and Child Health
Volume 48, Issue 2, pages E79–E83, February 2012
How to Cite
Malhotra, A., Hunt, R. W. and Doherty, R. R. (2012), Streptococcus pneumoniae sepsis in the newborn. Journal of Paediatrics and Child Health, 48: E79–E83. doi: 10.1111/j.1440-1754.2010.01929.x
- Issue published online: 9 FEB 2012
- Article first published online: 29 DEC 2010
- Accepted for publication 2 May 2010.
- streptococcus pneumoniae
Background: Streptococcus pneumoniae (SP) is an uncommon cause of neonatal sepsis.
Aims: To report on the spectrum of morbidity associated with SP infections in the neonatal period.
Methods: A case series of SP infection in the neonatal period was studied. Maternal and neonatal outcomes were noted.
Results: Four cases of neonatal SP infection are reported, one of which was due to a strain with reduced susceptibility to penicillin. All four cases had very early onset of severe clinical disease with bacteremia and pneumonia. In one case a retrospective diagnosis of meningitis was made as well. Maternal illness was a feature in one of these infants.
Conclusions: Although less common now than in the pre-antibiotic era, Streptococcus pneumoniae remains a rare but important cause of neonatal sepsis and can mimic early onset Group B streptococcal sepsis. It is unclear whether current infant or adult pneumococcal immunisation programs might influence its incidence in the neonatal period. The potential for strains with reduced susceptibility to β-lactam antibiotics to cause neonatal infection needs to be considered in relevant settings.