Obesity and the developmental origins of health and disease
Article first published online: 18 JAN 2011
© 2011 The Authors. Journal of Paediatrics and Child Health © 2011 Paediatrics and Child Health Division (Royal Australasian College of Physicians)
Journal of Paediatrics and Child Health
Volume 48, Issue 2, pages 86–90, February 2012
How to Cite
Kemp, M. W., Kallapur, S. G., Jobe, A. H. and Newnham, J. P. (2012), Obesity and the developmental origins of health and disease. Journal of Paediatrics and Child Health, 48: 86–90. doi: 10.1111/j.1440-1754.2010.01940.x
- Issue published online: 9 FEB 2012
- Article first published online: 18 JAN 2011
- Accepted for publication 20 May 2010.
The concept that environmental stimuli imparted on a developing organism have the potential to affect both its short- and long-term developmental profiles is intuitively appealing and, more importantly, supported by a growing body of experimental and observational evidence. A number of groups have posited model hypotheses in tandem with experimental data, linking extrinsic factors to the development of a host of human diseases. Here, we review the evolution of ‘the developmental origins of health and disease’ as a concept and discuss recent advances in the association of specific stimuli to obesity, an epidemic cause of human morbidity and mortality.