Sterile abscess formation associated with depot leuprorelin acetate therapy for central precocious puberty


Dr Stephanie R Johnson, Department of Endocrinology and Diabetes, Princess Margaret Hospital, Roberts Road, Subiaco, WA 6008, Australia; Fax: +61 8 9340 8605; email:


We describe a case of an 8 year old girl with central precocious puberty. She was commenced on 3 monthly intramuscular depot Leuprorelin acetate therapy, as a result of which she developed sterile abscesses. She was converted to daily subcutaneous Leuprorelin acetate therapy with no recurrence of the abscesses. The possible mechanisms for this reaction are described in the article.