Cerebral type of Lewy body disease
Article first published online: 30 OCT 2007
Volume 16, Issue 1, pages 32–35, March 1996
How to Cite
Kosaka, K., Iseki, E., Odawara, T. and Yamamoto, T. (1996), Cerebral type of Lewy body disease. Neuropathology, 16: 32–35. doi: 10.1111/j.1440-1789.1996.tb00152.x
- Issue published online: 30 OCT 2007
- Article first published online: 30 OCT 2007
- Received 7 September 1995; revised and accepted 30 October 1995.
- cortical Lewy body;
- diffuse Lewy body disease;
- Lewy body disease
A cerebral type of Lewy body disease (LBD) is proposed. Lewy body disease was split formerly into three types: brainstem type, transitional type and diffuse type. The diffuse type is now called diffuse Lewy body disease (DLBD). These three types are characterized pathologically by the presence of a large number of Lewy bodies in the CNS. In the brainstem type, Lewy bodies are numerous in the brainstem and diencephalon nuclei, and in DLBD, a vast number are present not only in these nuclei but also in the cerebral cortex and amygdala. In the cerebral type of LBD, as many Lewy bodies are found in the cerebral cortex and in the amygdala as there are in DLBD, but only rarely are they present in the brainstem and diencephalon nuclei. Thus, this type of LBD is different from other types in that it has no parkinson pathology. Therefore, parkinsonism fails to occur throughout the whole clinical course of this disease. The existence of a cerebral type of LBD suggests that Lewy bodies occur in the cerebral cortex earlier than in the brainstem nuclei and that cortical Lewy bodies appear even when the mesocortical dopaminergic system is intact. In addition, this might explain why dementia frequently precedes parkinsonism in DLBD.