Relationship between apoptosis and proliferation in secondary tumors of the brain
Article first published online: 26 NOV 2004
Volume 24, Issue 4, pages 302–305, December 2004
How to Cite
Vaquero, J., Zurita, M., Aguayo, C. and Coca, S. (2004), Relationship between apoptosis and proliferation in secondary tumors of the brain. Neuropathology, 24: 302–305. doi: 10.1111/j.1440-1789.2004.00569.x
- Issue published online: 26 NOV 2004
- Article first published online: 26 NOV 2004
- Received 26 January 2004; revised and accepted 22 March 2004.
- brain metastases;
- F7-26 marker;
- proliferative index
A correlation between apoptosis and proliferation in astrocytomas and oligodendrogliomas, but not in glioblastomas, has been previously reported. An index for apoptosis and proliferation was established for each tumor in a series of 20 brain metastases, and its correlation was studied using the Spearman rank correlation test. Apoptosis index (AI) ranged between 1 and 78% (mean ± SD: 11.48 ± 16.4). Proliferation index (PI) ranged between 2.4 and 21% (mean ± SD: 8.23 ± 4.8). When the relationship between AI and PI was studied, a clear correlation was found (r: 0.8965, 95% CI: 0.74–0.95; P < 0.0001). Therefore, it is concluded that a clear correlation exists between proliferation and apoptosis in secondary tumors of the brain.