Argyrophilic grain disease: A late-onset dementia with distinctive features among tauopathies
Article first published online: 26 NOV 2004
Volume 24, Issue 4, pages 269–283, December 2004
How to Cite
Tolnay, M. and Clavaguera, F. (2004), Argyrophilic grain disease: A late-onset dementia with distinctive features among tauopathies. Neuropathology, 24: 269–283. doi: 10.1111/j.1440-1789.2004.00591.x
- Issue published online: 26 NOV 2004
- Article first published online: 26 NOV 2004
- Received 31 August 2004 and accepted 3 September 2004.
- Alzheimer's disease;
- argyrophilic grain disease;
- four-repeat tauopathy;
- limbic dementia;
- tau gene haplotype
Argyrophilic grain disease (AgD) is a late-onset dementia morphologically characterized by the presence of abundant spindle-shaped argyrophilic grains (ArG) in neuronal processes and coiled bodies in oligodendrocytes. AgD changes consist of the microtubule-associated protein tau in an abnormally and hyperphosphorylated state and are mainly found in limbic regions, for example, in the hippocampus, the entorhinal and transentorhinal cortices and the amygdala. AgD shows a significant correlation with advancing age, and it became apparent from recent clinicopathological studies that it might account for approximately 5% of all dementia cases. Further immunohistochemical and biochemical studies revealed that AgD is a four-repeat (4R) tauopathy similar to PSP and corticobasal degeneration (CBD), but distinct from Alzheimer's disease (AD) and Pick's disease. Moreover, a common genetic background regarding the tau gene haplotype has been suggested for AgD, PSP and CBD. However, although there are currently only limited data available, AgD seems to be clinically distinct from PSP and CBD and shares rather features of (mild) AD or other forms of ‘limbic’ dementias, among them senile dementia with tangles and the localized form of AD.