Symposium: Synucleinopathies: Update
Animal models of Parkinson's disease: Similarities and differences between the disease and models
Article first published online: 18 SEP 2007
2007 Japanese Society of Neuropathology
Volume 27, Issue 5, pages 479–483, October 2007
How to Cite
Hattori, N. and Sato, S. (2007), Animal models of Parkinson's disease: Similarities and differences between the disease and models. Neuropathology, 27: 479–483. doi: 10.1111/j.1440-1789.2007.00842.x
- Issue published online: 18 SEP 2007
- Article first published online: 18 SEP 2007
- Received 17 April 2007; revised 24 May 2007 and accepted 25 May 2007.
- Parkinson's disease
Parkinson's disease (PD) is a progressive movement disorder characterized by resting tremor, rigidity, akinesia, and postural instability. In addition, PD is characterized by the appearance of Lewy bodies in the remaining neurons. The exact etiology for this disease is still unknown. However, genetic–environmental interaction could contribute to the pathomechanisms of PD. Indeed, seven causative genes responsible for familial PD have been identified. Since discovery of familial PD (FPD), genetic PD models have been developed. Moreover, new PD models using neurotoxins have been reported. In this review, the similarities between human PD and PD models such as genetic mice and Drosophila models are reviewed.