Polar spongioblastoma: A high-grade glioma that does not contain the IDH1 mutation or 1p/19q LOH
Article first published online: 19 JAN 2010
© 2010 Japanese Society of Neuropathology
Volume 30, Issue 5, pages 547–552, October 2010
How to Cite
Nagaishi, M., Tanaka, Y., Iwatate, K., Yokoo, H., Ueki, K., Hyodo, A. and Nakazato, Y. (2010), Polar spongioblastoma: A high-grade glioma that does not contain the IDH1 mutation or 1p/19q LOH. Neuropathology, 30: 547–552. doi: 10.1111/j.1440-1789.2009.01087.x
- Issue published online: 19 JAN 2010
- Article first published online: 19 JAN 2010
- Received 18 October 2009; revised 16 November 2009 and accepted 17 November 2009; published online 19 January 2010.
- isocitrate dehydrogenase (IDH);
- O-6-methylguanine-DNA methyltransferase (MGMT);
- polar spongioblastoma
We report a case of an unusual glioma termed “primitive polar spongioblastoma” that displayed characteristic palisading tumor cells at the light microscopic level. The patient was a 52-year-old woman who underwent subtotal removal for a left frontotemporal tumor. The palisading pattern was present throughout the tumor. Several glial markers were revealed by immunohistochemical examination, but no neuronal markers were observed. Genetic studies showed O-6-methylguanine-DNA methyltransferase (MGMT) methylation, wild type IDH1, and the absence of 1p/19q loss of heterozygosity (LOH) in the tumor genes. Based on histological and genetic features, this tumor might not be suited to any of neuroepithelial tumor in the recent WHO classification. We consider that cases such as this should be temporarily set under a separate heading and be entrusted to future investigation after more cases have been accumulated.