The pathology of methylmercury poisoning (Minamata disease)
The 50th Anniversary of Japanese Society of Neuropathology
Article first published online: 24 MAY 2010
© 2010 Japanese Society of Neuropathology
Volume 30, Issue 5, pages 471–479, October 2010
How to Cite
Eto, K., Marumoto, M. and Takeya, M. (2010), The pathology of methylmercury poisoning (Minamata disease). Neuropathology, 30: 471–479. doi: 10.1111/j.1440-1789.2010.01119.x
- Issue published online: 24 MAY 2010
- Article first published online: 24 MAY 2010
- Received 18 February 2010 and accepted 8 March 2010; published online 24 May 2010.
- human autopsy cases;
- methylmercury poisoning;
- Minamata disease;
- three types of Minamata disease
Methylmercury (Me-Hg) poisoning (Minamata disease: MD) is one of the most severe types of disease caused by humans to humans in Japan. The disease is a special class of food-borne methylmercury intoxication in humans as typified by the outbreak that began in 1953 in Minamata and its vicinity in Kumamoto Prefecture, Japan. There are 450 autopsy cases in Kumamoto and 30 autopsy cases in Niigata Prefecture related to MD in Japan. Two hundred and one cases in Kumamoto and 22 cases in Niigata showed pathological changes of MD. This report provides a brief research history and overview of the pathological changes of MD, and also presents representative cases of adult, infantile and fetal forms of MD among the 450 MD-related autopsy cases in Kumamoto Prefecture.