• 1
    Hinuma Y, Nagata K, Hanaoka M et al. Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sci USA 1981; 78: 64766480.
  • 2
    Osame M, Usuku K, Izumo S et al. HTLV-I associated myelopathy, a new clinical entity. Lancet 1986; i: 10311032.
  • 3
    Gessain A, Barin F, Vernant JC et al. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet 1985; ii: 407410.
  • 4
    Nakagawa M, Izumo S, Ijichi S et al. HTLV-I-associated myelopathy: analysis of 213 patients based on clinical features and laboratory findings. J Neurovirol 1995; 1: 5061.
  • 5
    Akizuki S, Nakazato Y, Higuchi Y et al. Necropsy findings in HTLV-1 associated myelopathy (letter). Lancet 1987; i: 156157.
  • 6
    Izumo S, Usuku K, Osame M et al. The neuropathology of HTLV-1-associated myelopathy in Japan – report of an autopsy case and review of the literature. In: RomanGC, VernantJC, OsameM, eds. HTLV-1 and the Nervous System. New York: Alan R. Liss, 1989; 261267.
  • 7
    Iwasaki Y. Pathology of chronic myelopathy associated with HTLV-I infection (HAM/TSP). J Neurol Sci 1990; 96: 103123.
  • 8
    Umehara F, Izumo S, Nakagawa M et al. Immunocytochemical analysis of the cellular infiltrate in the spinal cord lesions in HTLV-1-associated myelopathy. J Neuropathol Exp Neurol 1993; 52: 424430.
  • 9
    Umehara F, Izumo S, Ronquillo AT et al. Cytokine expression in the spinal cord lesions in HTLV-1-associated myelopathy. J Neuropathol Exp Neurol 1994; 53: 7277.
  • 10
    Umehara F, Izumo S, Takeya M et al. Expression of adhesion molecules and monocyte chemoattractant protein-1 (MCP-1) in the spinal cord lesions in HTLV-1-associated myelopathy. Acta Neuropathol 1996; 91: 343350.
  • 11
    Umehara F, Nakamura A, Izumo S et al. Apoptosis of T lymphocytes in the spinal cord lesions in HTLV-1-associated myelopathy: a possible mechanism to control viral infection in the central nervous system. J Neuropathol Exp Neurol 1994; 53: 617624.
  • 12
    Kubota R, Umehara F, Izumo S et al. Correlation between HTLV-1 proviral DNA amount and infiltrating CD4+ lymphocytes in the affected spinal cord from patients with HTLV-1-associated myelopathy. J Neuroimmunol 1994; 53: 2329.
  • 13
    Matsuoka E, Takenouchi N, Hashimoto K et al. Perivascular T cells are infected with HTLV-I in the spinal cord lesions with HTLV-I-associated myelopathy/tropical spastic paraparesis: double staining of immunohistochemistry and polymerase chain reaction in situ hybridization. Acta Neuropathol 1998; 96: 340346.
  • 14
    Moritoyo T, Reinhart TA, Moritoyo H et al. Human T-lymphotropic virus type I-associated myelopathy and tax gene expression in CD4+ T lymphocytes. Ann Neurol 1996; 40: 8490.
  • 15
    Aye MM, Matsuoka E, Moritoyo T et al. Histopathological analysis of four autopsy cases of HTLV-I-associated myelopathy/tropical spastic paraparesis: inflammatory changes occur simultaneously in the entire central nervous system. Acta Neuropathol 2000; 100: 245252.
  • 16
    Umehara F, Okada Y, Fujimoto N et al. Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in HTLV-I-associated myelopathy. J Neuropathol Exp Neurol 1998; 57: 839849.
  • 17
    Matsuoka E, Usuku K, Jonosono M et al. CD44 splice variant involvement in the chronic inflammatory disease of the spinal cord: HAM/TSP. J Neuroimmunol 2000; 102: 17.
  • 18
    Ijichi S, Izumo S, Eiraku N et al. An autoaggresive process against by stander tissues in HTLV-1-infected individuals: a possible pathomechanism of HAM/TSP. Med Hypotheses 1993; 41: 542547.