Diagnostic implications of histological analysis of neurosurgical aspirate in addition to routine resections
Article first published online: 21 JUN 2011
© 2011 Japanese Society of Neuropathology
Volume 32, Issue 1, pages 44–50, February 2012
How to Cite
Zadeh, G., Salehi, F., An, S., Uff, C., Camp, S., Revesz, T., Holton, J., Thom, M., McEvoy, A. W., Grieve, J., Kitchen, N. and Brandner, S. (2012), Diagnostic implications of histological analysis of neurosurgical aspirate in addition to routine resections. Neuropathology, 32: 44–50. doi: 10.1111/j.1440-1789.2011.01234.x
- Issue published online: 16 JAN 2012
- Article first published online: 21 JUN 2011
- Received 15 March 2011; revised 4 April 2011 and accepted 26 April 2011.
- cavitron ultrasonic surgical aspirator (CUSA);
- CNS tumor;
- surgical aspirate
Many neurosurgical centers use surgical aspirators to remove brain tumor tissue. The resulting aspirate consists of fragmented viable tumor, normal or tumor-infiltrated brain tissue as well as necrotic tissue, depending on the type of tumor. Typically, such fragmented aspirate material is collected but discarded and not included when making the histopathological diagnosis. Whereas the general suitability of surgical aspirate for histological diagnosis and immunohistochemical staining has been reported previously, we have systematically investigated whether the collection and histological examination of surgical aspirate has an impact on diagnosis, in particular on the tumor grading, by providing additional features. Surgical and aspirate specimens from 85 consecutive neurosurgical procedures were collected and routinely processed. Sixty-five of the 85 specimens were intrinsic brain tumors and the remainder consisted of metastatic tumors, meningiomas, schwannomas and lymphomas. Important diagnostic features seen in surgical aspirate were microvascular proliferation (n = 3), more representative necrosis (n = 2), and gemistocytic component (n = 2). In one case, microvasular proliferations were seen in the aspirate only, leading to a change of diagnosis. Collection of surgical aspirate also generates additional archival material which can be microdissected and used for tissue microarrays or for molecular studies.