Relationship of predialytic intact parathyroid hormone on secondary hyperparathyroidism in chronic maintenance haemodialysis patients

Authors

  • SATOSHI ETOH,

    Corresponding author
    1. Division of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University School of Medicine and Kawanami Hospital Kidney Center, Fukuoka, Japan
      Dr Satoshi Etoh, Division of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. Email: etohs@minf.med.fukuoka-u.ac.jp
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  • TOSHIAKI MURATA,

    1. Division of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University School of Medicine and Kawanami Hospital Kidney Center, Fukuoka, Japan
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  • YOSHIYUKI HASEGAWA,

    1. Division of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University School of Medicine and Kawanami Hospital Kidney Center, Fukuoka, Japan
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  • YOSHITO MIYAHARA,

    1. Division of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University School of Medicine and Kawanami Hospital Kidney Center, Fukuoka, Japan
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  • ATUNORI ISHIMURA,

    1. Division of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University School of Medicine and Kawanami Hospital Kidney Center, Fukuoka, Japan
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  • YASUHIRO ABE,

    1. Division of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University School of Medicine and Kawanami Hospital Kidney Center, Fukuoka, Japan
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  • RITSUYA NODA,

    1. Division of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University School of Medicine and Kawanami Hospital Kidney Center, Fukuoka, Japan
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  • SATORU OGAHARA,

    1. Division of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University School of Medicine and Kawanami Hospital Kidney Center, Fukuoka, Japan
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  • HIDETOSHI KANEOKA,

    1. Division of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University School of Medicine and Kawanami Hospital Kidney Center, Fukuoka, Japan
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  • TAKAO SAITO

    1. Division of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University School of Medicine and Kawanami Hospital Kidney Center, Fukuoka, Japan
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Dr Satoshi Etoh, Division of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. Email: etohs@minf.med.fukuoka-u.ac.jp

SUMMARY:

Methods and Results:  In order to clarify the predialytic factors influencing the onset of secondary hyperparathyroidism (SHPT) in patients on chronic maintenance haemodialysis, the time-course changes of serum levels of intact-PTH (i-PTH) during haemodialysis for 5 years were investigated. The subjects were 69 non-diabetic patients who had a serum aluminium level of less than 1.85 nmol/L at the end of observation. Patients were divided into two groups based on i-PTH levels obtained at the start of dialysis; the high group (H group) consisted of patients whose i-PTH levels were more than 22.00 pmol/L, the low group (L group) had levels less than 22.00 pmol/L. In the H group, i-PTH was 41.46 ± 2.87 pmol/L at the start of dialysis (vs L group, P < 0.0001) and 15.82 ± 2.85 pmol/L after haemodialysis initiation. In the L group, i-PTH levels did not significantly change and was 11.69 ± 2.50 pmol/L 12 months after the start of dialysis (at the 12th month). However, at the 60th month, the i-PTH level was 33.24 ± 5.30 pmol/L in the H group, and 9.85 ± 2.13 pmol/L in the L group (P < 0.005).

Conclusion:  It is suggested that control of i-PTH levels in the predialytic period may be important to suppress SHPT throughout haemodialysis.

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