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Keywords:

  • darbepoietin;
  • erythropoietin;
  • hypersensitivity;
  • polysorbate

SUMMARY:  The following case reports are of two patients who have developed hypersensitivity reactions to the red cell growth hormones, darbepoietin and erythropoietin. The subsequent skin testing and clinical course suggested that the cause of these reactions was due to the excipient polysorbate 80. This finding might have implications in the recent increase in the incidence of pure red cell aplasia.