• 1
    Kreidberg JA. Podocyte differentiation and glomerulogenesis. J. Am. Soc. Nephrol. 2003; 14: 80614.
  • 2
    Haber DA, Sohn RL, Buckler AJ, Pelletier J, Call KM, Housman DE. Alternative splicing and genomic structure of the Wilms tumor gene WT1. Proc. Natl. Acad. Sci. USA 1991; 88: 961822.
  • 3
    Kreidberg JA, Sariola H, Loring JM et al. WT-1 is required for early kidney development. Cell 1993; 74: 67991.
  • 4
    Palmer RE, Kotsianti A, Cadman B, Boyd T, Gerald W, Haber DA. WT1 regulates the expression of the major glomerular podocyte membrane protein podocalyxin. Curr. Biol. 2001; 11: 18059.
  • 5
    Hammes A, Guo JK, Lutsch G et al. Two splice variants of the Wilms’ tumor 1 gene have distinct functions during sex determination and nephron formation. Cell 2001; 106: 31929.
  • 6
    Torres M, Gómez-Pardo E, Dressler GR, Gruss P. Pax-2 controls multiple steps of urogenital development. Development 1995; 121: 405765.
  • 7
    Ryan G, Steele-Perkins V, Morris JF, Rauscher FJ 3rd, Dressler GR. Repression of Pax-2 by WT1 during normal kidney development. Development 1995; 121: 86775.
  • 8
    Dreyer SD, Zhou G, Baldini A et al. Mutations in LMX1B cause abnormal skeletal patterning and renal dysplasia in nail patella syndrome. Nat. Genet. 1998; 19: 4750.
  • 9
    Rohr C, Prestel J, Heidet L et al. The LIM-homeodomain transcription factor Lmx1b plays a crucial role in podocytes. J. Clin. Invest. 2002; 109: 107382.
  • 10
    Quaggin SE, Vanden Heuvel GB, Igarashi P. Pod-1, a mesoderm-specific basic-helix-loop-helix protein expressed in mesenchymal and glomerular epithelial cells in the developing kidney. Mech. Develop. 1998; 71: 3748.
  • 11
    Imaki J, Onodera H, Tsuchiya K et al. Developmental expression of maf-1 messenger ribonucleic acids in rat kidney by in situ hybridization histochemistry. Biochem. Bioph. Res. Co. 2000; 272: 77782.
  • 12
    Kume T, Deng K, Hogan BL. Minimal phenotype of mice homozygous for a null mutation in the forkhead/winged helix gene, Mf2. Mol. Cell. Biol. 2000; 20: 141925.
  • 13
    Patrakka J, Kestila M, Wartiovaara J et al. Congenital nephrotic syndrome (NPHS1): Features resulting from different mutations in Finnish patients. Kidney Int. 2000; 58: 97280.
  • 14
    Ruotsalainen V, Ljungberg P, Wartiovaara J et al. Nephrin is specifically located at the slit diaphragm of glomerular podocytes. Proc. Natl. Acad. Sci. USA 1999; 96: 79627.
  • 15
    Orikasa M, Matsui K, Oite T, Shimizu F. Massive proteinuria induced in rats by a single intravenous injection of a monoclonal antibody. J. Immunol. 1988; 141: 80714.
  • 16
    Putaala H, Soininen R, Kilpelainen P, Wartiovaara J, Tryggvason K. The murine nephrin gene is specifically expressed in kidney, brain and pancreas: Inactivation of the gene leads to massive proteinuria and neonatal death. Hum. Mol. Genet. 2001; 10: 18.
  • 17
    Huber TB, Kottgen M, Schilling B, Walz G, Benzing T. Interaction with podocin facilitates nephrin signaling. J. Biol. Chem. 2001; 276: 41 543–6.
  • 18
    Furness PN, Hall LL, Shaw JA, Pringle JH. Glomerular expression of nephrin is decreased in acquired human nephrotic syndrome. Nephrol. Dialysis Transplantation 1999; 14: 12347.
  • 19
    Patrakka J, Ruotsalainen V, Ketola I et al. Expression of nephrin in pediatric kidney diseases. J. Am. Soc. Nephrol. 2001; 12: 28996.
  • 20
    Wang SX, Rastaldi MP, Patari A, Ahola H, Heikkila E, Holthofer H. Patterns of nephrin and a new proteinuria-associated protein expression in human renal diseases. Kidney Int. 2002; 61: 1417.
  • 21
    Kim BK, Hong HK, Kim JH, Lee HS. Differential expression of nephrin in acquired human proteinuric diseases. Am. J. Kidney Dis. 2002; 40: 96473.
  • 22
    Boute N, Gribouval O, Roselli S et al. NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. Nat. Genet. 2000; 24: 34954.
  • 23
    Tsukaguchi H, Sudhakar A, Le TC et al. NPHS2 mutations in late-onset focal segmental glomerulosclerosis: R229Q is a common disease-associated allele. J. Clin. Invest. 2002; 110: 165966.
  • 24
    Pereira AC, Pereira AB, Mota GF et al. NPHS2 R229Q functional variant is associated with microalbuminuria in the general population. Kidney Int. 2004; 65: 102630.
  • 25
    Dustin ML, Olszowy MW, Holdorf AD et al. A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts. Cell 1998; 94: 66777.
  • 26
    Schwarz K, Simons M, Reiser J et al. Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin. J. Clin. Invest. 2001; 108: 16219.
  • 27
    Huber TB, Hartleben B, Kim J et al. Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling. Mol. Cell. Biol. 2003; 23: 491728.
  • 28
    Schiffer M, Mundel P, Shaw AS, Bottinger EP. A novel role for the adaptor molecule CD2-associated protein in transforming growth factor-beta-induced apoptosis. J. Biol. Chem. 2004; 279: 37 004–12.
  • 29
    Kim JM, Wu H, Green G et al. CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility. Science 2003; 300: 1298300.
  • 30
    Sellin L, Huber TB, Gerke P, Quack I, Pavenstadt H, Walz G. NEPH1 defines a novel family of podocin interacting proteins. FASEB. J. 2003; 17: 11517.
  • 31
    Kaplan JM, Kim SH, North KN et al. Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis. Nat. Genet. 2000; 24: 2516.
  • 32
    Yao J, Le TC, Kos CH et al. Alpha-actinin-4-mediated FSGS: An inherited kidney disease caused by an aggregated and rapidly degraded cytoskeletal protein. Plos. Biol. 2004; 2: 78794.
  • 33
    Mundel P, Heid HW, Mundel TM, Kruger M, Reiser J, Kriz W. Synaptopodin: An actin-associated protein in telencephalic dendrites and renal podocytes. J. Cell Biol. 1997; 139: 193204.
  • 34
    Schmid H, Henger A, Cohen CD et al. Gene expression profiles of podocyte-associated molecules as diagnostic markers in acquired proteinuric diseases. J. Am. Soc. Nephrol. 2003; 14: 295866.
  • 35
    Kretzler M, Teixeira VP, Unschuld PG et al. Integrin-linked kinase as a candidate downstream effector in proteinuria. FASEB J. 2001; 15: 18435.
  • 36
    Maynard SE, Min JY, Merchan J et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J. Clin. Invest. 2003; 111: 64958.
  • 37
    Sugimoto H, Hamano Y, Charytan D et al. Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria. J. Biol. Chem. 2003; 278: 12 605–8.
  • 38
    Eremina V, Sood M, Haigh J et al. Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J. Clin. Invest. 2003; 111: 70716.
  • 39
    Satchell SC, Harper SJ, Tooke JE, Kerjaschki D, Saleem MA, Mathieson PW. Human podocytes express angiopoietin 1, a potential regulator of glomerular vascular endothelial growth factor. J. Am. Soc. Nephrol. 2002; 13: 54450.
  • 40
    Pagtalunan ME, Miller PL, Jumping-Eagle S et al. Podocyte loss and progressive glomerular injury in type II diabetes. J. Clin. Invest. 1997; 99: 3428.
  • 41
    Steffes MW, Schmidt D, McCrery R, Basgen JM, International Diabetic Nephropathy Study Group. Glomerular cell number in normal subjects and in type 1 diabetic patients. Kidney Int. 2001; 59: 210413.
  • 42
    Nagata M, Nakayama K, Terada Y, Hoshi S, Watanabe T. Cell cycle regulation and differentiation in the human podocyte lineage. Am. J. Pathol. 1998; 153: 151120.
  • 43
    Kriz W, Gretz N, Lemley KV. Progression of glomerular diseases: Is the podocyte the culprit? Kidney Int. 1998; 54: 68797.
  • 44
    Mundel P, Reiser J, Zuniga Mejia Borja A et al. Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines. Exp. Cell Res. 1997; 236: 24858.
  • 45
    Saleem MA, O'Hare MJ, Reiser J et al. A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression. J. Am. Soc. Nephrol. 2002; 13: 63038.
  • 46
    Schiwek D, Endlich N, Holzman L, Holthofer H, Kriz W, Endlich K. Stable expression of nephrin and localization to cell-cell contacts in novel murine podocyte cell lines. Kidney Int. 2004; 66: 91101.
  • 47
    Takemoto M, Asker N, Gerhardt H et al. A new method for large scale isolation of kidney glomeruli from mice. Am. J. Pathol. 2002; 161: 799805.
  • 48
    Eremina V, Wong MA, Cui S, Schwartz L, Quaggin SE. Glomerular-specific gene excision in vivo. J. Am. Soc. Nephrol. 2002; 13: 78893.
  • 49
    Bugeon L, Danou A, Carpentier D, Langridge P, Syed N, Dallman MJ. Inducible gene silencing in podocytes: A new tool for studying glomerular function. J. Am. Soc. Nephrol. 2003; 14: 78691.
  • 50
    Pavenstadt H, Kriz W, Kretzler M. Cell biology of the glomerular podocyte. Physiol. Rev. 2003; 83: 253307.