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Dengue has a benign presentation in renal transplant patients: A case series

Authors


Dr Claude Jeffrey Renaud, Division of Nephrology, Department of Medicine, National University Hospital, 5 Lower Kentridge Road, Singapore 119074. Email: claude_jeffrey_renaud@nuh.com.sg

SUMMARY:

Aim:  Dengue fever and its complications are a poorly described entity in the renal transplant population. Previous reports in renal transplant patients suggest a high mortality rate.

Methods:  We undertook a retrospective study of six cases of dengue fever in renal transplant patients during a dengue outbreak in Singapore in 2005 which involved a total of 1400 cases in the city state.

Results:  Mean thrombocytopenia was 130 000/μL on presentation and 80 000/μL at deffervescence. No dengue haemorrhagic fever, dengue shock syndrome, deaths or abnormal graft function were observed. Mean hospital stay was 8.6 days. Four of six patients also had simultaneous CMV reactivation.

Conclusion:  In common with the majority of adults, dengue fever follows a benign course in the renal transplant population and dengue haemorrhagic fever is rare. This may be related to the relative immunosuppression reducing the risk for antibody-enhanced complications.

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