Revascularization for post-transplant renal artery stenosis
Article first published online: 10 MAY 2007
Volume 12, Issue 4, pages 406–412, August 2007
How to Cite
CHOW, K. M., SZETO, C. C., LEE, P. S. F., HO, S. S. M., LEUNG, C. B. and LI, P. K.-T. (2007), Revascularization for post-transplant renal artery stenosis. Nephrology, 12: 406–412. doi: 10.1111/j.1440-1797.2007.00801.x
- Issue published online: 10 MAY 2007
- Article first published online: 10 MAY 2007
- Accepted for publication 2 February 2007.
- blood pressure;
- percutaneous transluminal angioplasty;
- transplant renal artery stenosis
Background: Percutaneous transluminal angioplasty has now been increasingly accepted as a primary treatment option for transplant renal artery stenosis.
Methods: This single-centre study evaluated the treatment effect of percutaneous transluminal angioplasty as primary intervention among 18 consecutive patients with angiographically demonstrated transplant renal artery stenosis.
Results: Patients (14 men and 4 women, mean age 49 ± 9 years) were followed up for a mean duration of 21.6 months after procedure. Highly significant improvement was noted in the mean arterial pressure (from baseline 105.9 ± 10.4 mmHg to 98.6 ± 10.0 mmHg, P < 0.001), systolic blood pressure (148.5 mmHg to 137.1 mmHg, P = 0.002) and diastolic blood pressure (85.3 mmHg to 79.4 mmHg, P = 0.002). Estimated glomerular filtration rate before and 6 months after intervention was 41.4 ± 16.8 mL/min per 1.73 m2 and 42.0 ± 16.2 mL/min per 1.73 m2, respectively (P = 0.82).
Conclusion: These findings show that percutaneous transluminal angioplasty in transplant renal artery stenosis appears to have a significant beneficial effect on hypertension but less impact on the improvement in renal function.