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Keywords:

  • blood pressure;
  • hypertension;
  • percutaneous transluminal angioplasty;
  • stent;
  • transplant renal artery stenosis

SUMMARY:

Background:  Percutaneous transluminal angioplasty has now been increasingly accepted as a primary treatment option for transplant renal artery stenosis.

Methods:  This single-centre study evaluated the treatment effect of percutaneous transluminal angioplasty as primary intervention among 18 consecutive patients with angiographically demonstrated transplant renal artery stenosis.

Results:  Patients (14 men and 4 women, mean age 49 ± 9 years) were followed up for a mean duration of 21.6 months after procedure. Highly significant improvement was noted in the mean arterial pressure (from baseline 105.9 ± 10.4 mmHg to 98.6 ± 10.0 mmHg, P < 0.001), systolic blood pressure (148.5 mmHg to 137.1 mmHg, P = 0.002) and diastolic blood pressure (85.3 mmHg to 79.4 mmHg, P = 0.002). Estimated glomerular filtration rate before and 6 months after intervention was 41.4 ± 16.8 mL/min per 1.73 m2 and 42.0 ± 16.2 mL/min per 1.73 m2, respectively (P = 0.82).

Conclusion:  These findings show that percutaneous transluminal angioplasty in transplant renal artery stenosis appears to have a significant beneficial effect on hypertension but less impact on the improvement in renal function.