Lack of association between NPHS2 gene polymorphisms and sporadic IgA nephropathy

Authors


Dr Yang Zhang, Department of Epidemiology, Zhejiang University School of Medicine, Hangzhou 310031, Zhejiang Province, China. E-mail: zhangy@zju.edu.cn

SUMMARY:

Aim:  IgA nephropathy (IgAN) is the most common primary form of glomerulonephritis worldwide. In the present study, the genetic structure of the NPHS2 gene was studied to verify if podocin plays a role in the pathogenesis of IgAN.

Methods:  Clinical characteristics and DNA samples were collected from 26 Chinese children with sporadic IgAN. A direct sequencing was performed after polymerase chain reaction amplification to all the eight exons of the NPHS2 gene.

Results:  Three synonymous variants as known polymorphisms (954T→C homozygous, 1038A→G heterozygous and homozygous) were found in 3, 4 and 1 patients, respectively. There was no significant difference in the genotypic and allelic frequencies of 954T > C and 1038A > G polymorphisms between the patients and normal controls.

Conclusion:  No significant difference in the genotypic and allelic frequencies of the identified 954T > C and 1038A > G polymorphisms between the patients and normal controls was found.

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