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Renal biopsy in type 2 diabetes: Timing of complications and evaluating of safety in Chinese patients
Article first published online: 5 JUL 2010
DOI: 10.1111/j.1440-1797.2010.01369.x
© 2011 The Authors. Nephrology © 2011 Asian Pacific Society of Nephrology
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How to Cite
ZHANG, P.-P., GE, Y.-C., LI, S.-J., XIE, H.-L., LI, L.-S. and LIU, Z.-H. (2011), Renal biopsy in type 2 diabetes: Timing of complications and evaluating of safety in Chinese patients. Nephrology, 16: 100–105. doi: 10.1111/j.1440-1797.2010.01369.x
Publication History
- Issue published online: 23 DEC 2010
- Article first published online: 5 JUL 2010
- Accepted manuscript online: 5 JUL 2010 12:00AM EST
- Accepted for publication 14 June 2010.Accepted manuscript online 5 July 2010.
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Keywords:
- diabetic nephropathy;
- gross haematuria;
- haematoma;
- pathological diagnosis;
- renal biopsy
ABSTRACT
Aim: It has been recognized that renal lesions in patients with diabetes often have other causes of renal damage concomitantly. Renal biopsy is a valuable tool to provide histological evidence. However, the safety in patients with type 2 diabetes receiving renal biopsy is not well evaluated. This study was conducted to monitor the dynamic complications and to evaluate the safety of biopsy in diabetic patients.
Methods: A prospective observation was performed on 130 patients with type 2 diabetes and 150 patients not undergoing renal biopsy. The complications were monitored at 4 h, 8 h, 24 h, 48 h and 72 h sequentially after biopsy.
Results: Haematoma was observed in 34 (26.15%) patients with diabetes and 50 (33.33%) in controls (P = 0.19). The timing of large haematoma peaked at 4 h. Gross haematuria occurred in 12 (9.23%) diabetic patients and eight (5.33%) controls (P = 0.207). It happened mainly within 8 h. Renal pathological diagnosis showed 96 (73.85%) cases with diabetic nephropathy and 34 (26.15%) cases with non-diabetic renal disease.
Conclusion: Renal biopsy in patients with type 2 diabetes is safe. The frequency of complications after renal biopsy in diabetes is no higher than those without diabetes. The complications mostly happened within 8 h, especially within 4 h. Biopsy is also very necessary to rule out other chronic renal diseases in diabetes.