The authors have no conflict of interest.
Does a reduction in dialysate sodium improve blood pressure control in haemodialysis patients?
Version of Record online: 17 APR 2012
© 2012 The Authors. Nephrology © 2012 Asian Pacific Society of Nephrology
Volume 17, Issue 4, pages 358–363, May 2012
How to Cite
SHAH, A. and DAVENPORT, A. (2012), Does a reduction in dialysate sodium improve blood pressure control in haemodialysis patients?. Nephrology, 17: 358–363. doi: 10.1111/j.1440-1797.2012.01576.x
The data contained in this paper have not been published in whole or part form, or abstract presentations.
- Issue online: 17 APR 2012
- Version of Record online: 17 APR 2012
- Accepted manuscript online: 3 FEB 2012 04:50AM EST
- Accepted for publication 14 January 2012.; Accepted manuscript online 3 February 2012.
- dialysate sodium;
Introduction: There has been debate as to the value of lower sodium dialysates to control blood pressure in haemodialysis patients, as sodium is predominantly removed by ultrafiltration.
Methods: Re-audit of clinical practice following reduction in dialysate sodium concentration.
Results: Overall dialysate sodium concentration decreased from 138.9 ± 1.7 to 137.8 ± 1.7 mmol/L (mean ± standard deviation), resulting in a reduction in pre- and post-dialysis mean arterial pressure (MAP) of 4 mmHg (from 100.6 ± 15.6 to 97.1 ± 15.6, P < 0.01 and from 91.7 ± 15.6 to 87.1 ± 14.6, P < 0.001 respectively), yet fewer patients were prescribed antihypertensives (49.6 vs 60.6%), and less antihypertensive medications/patient (mean 0.86 vs 1.05), ultrafiltration requirements (2.8% vs 3.2% body weight, P < 0.001), and symptomatic intradialytic hypotension (0.19 vs 0.28 episodes per week, P < 0.001). A multivariable model showed that for a dialysate sodium of 136 mmol/L, younger patients had higher MAP than older patients (0.35 mmHg lower MAP/year older; but with a dialysate sodium of 140 mmol/L, there was minimal association of MAP with age (0.07 mmHg higher MAP/year older).
Conclusion: Change in clinical practice, amounting to a modest reduction in dialysate sodium was associated with a reduction not only in pre- and post-dialysis blood pressures, but also ultrafiltration requirements and symptomatic intradialytic hypotension. However, this effect on blood pressure was most marked for older patients and women, within minimal effects for younger patients, and lesser effects for men, suggesting that dialysate sodium reduction alone may help improve blood pressure control, but requires additional factors such as dietary sodium restriction to be effective in younger male patients.