Association between vitamin C deficiency and dialysis modalities
Article first published online: 24 JUN 2012
© 2012 The Authors. Nephrology © 2012 Asian Pacific Society of Nephrology
Volume 17, Issue 5, pages 452–457, July 2012
How to Cite
ZHANG, K., DONG, J., CHENG, X., BAI, W., GUO, W., WU, L. and ZUO, L. (2012), Association between vitamin C deficiency and dialysis modalities. Nephrology, 17: 452–457. doi: 10.1111/j.1440-1797.2012.01595.x
- Issue published online: 24 JUN 2012
- Article first published online: 24 JUN 2012
- Accepted manuscript online: 9 MAR 2012 01:04AM EST
- Accepted for publication 5 March 2012.; Accepted manuscript online 9 March 2012.
- peritoneal dialysis;
- vitamin C deficiency
Aim: We designed a cross-sectional study to investigate plasma vitamin C level in patients who underwent maintenance haemodialysis (MHD) and continuous ambulatory peritoneal dialysis (CAPD) to explore whether there is a difference in vitamin C deficiency between MHD patients and CAPD patients.
Methods: This investigation included 382 dialysis patients without vitamin C supplement before the study. Demographic characteristics, laboratory tests, ascorbic acid and total plasma vitamin C level were measured. A linear regression model was built to explore the association between vitamin C deficiency and dialysis modalities after adjusting for age, dialysis vintage, gender, Charlson index, modality of dialysis and hsCRP.
Results: The range of plasma vitamin C level was from 0.48 µg/mL to 31.16 µg/mL. 35.9% (n = 137) patients had severe vitamin C deficiency (<2 µg/mL). Plasma vitamin C level was inversely associated with age and dialysis vintage. After age and dialysis vintage were adjusted, vitamin C deficiency was associated with MHD. R square for model fitting was relatively low, which implied that there were other vitamin C influencing factors not included in the model.
Conclusions: Vitamin C deficiency is common in dialysis patients, especially in patients treated with MHD.