Effect of statins on chronic inflammation and nutrition status in renal dialysis patients: A systematic review and meta-analysis
Article first published online: 23 JUL 2012
© 2012 The Authors. Nephrology © 2012 Asian Pacific Society of Nephrology
Volume 17, Issue 6, pages 545–551, August 2012
How to Cite
DENG, J., WU, Q., LIAO, Y., HUO, D. and YANG, Z. (2012), Effect of statins on chronic inflammation and nutrition status in renal dialysis patients: A systematic review and meta-analysis. Nephrology, 17: 545–551. doi: 10.1111/j.1440-1797.2012.01597.x
- Issue published online: 23 JUL 2012
- Article first published online: 23 JUL 2012
- Accepted manuscript online: 19 MAR 2012 11:25AM EST
- Accepted for publication 9 March 2012.; Accepted manuscript online 19 March 2012.
- chronic inflammation;
- renal dialysis;
- systematic review
Aim: 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) may have an adjunctive effect on chronic inflammation and nutrition status in renal dialysis patients. Therefore, we performed a systematic review of randomized controlled trials to assess the effect of statins on chronic inflammation and nutrition status in dialysis patients.
Methods: The randomized controlled trials (RCTs) of statins versus placebo or no treatment for renal dialysis patients were searched from PubMed, EMbase and Cochran Central Register of Controlled Trials. We screened relevant studies according to predefined inclusion and exclusion criteria, evaluated the quality of the included studies, and performed meta-analyses by using the Cochrane Collaboration's Revman 5.1 software.
Results: We identified nine trials including 3098 patients. Meta-analysis showed statins can significantly decrease the serum C-reactive protein (CRP) (SMD, −0.54; 95% confidence interval (CI), −1.04 to −0.05; P = 0.03) and high sensitivity CRP (hs-CRP) level (SMD, −0.72; 95% CI, −1.14 to −0.31; P = 0.0007) of dialysis patients compared with that of the control group. However, statins did not differ significantly from the control group in increasing the serum Alb level (SMD, −0.13; 95% CI, −0.42 to 0.15; P = 0.37).
Conclusions: Statins can improve the chronic inflammation status reflected by the decreasing of serum CRP and hs-CRP levels, whereas there is no conclusive evidence that it can improve the nutrition status. However, this result needs to be further confirmed in more high-quality randomized clinical trials.