Impact of metabolic syndrome on the incidence of chronic kidney disease: A Chinese cohort study
Article first published online: 23 JUL 2012
© 2012 The Authors. Nephrology © 2012 Asian Pacific Society of Nephrology
Volume 17, Issue 6, pages 532–538, August 2012
How to Cite
YANG, T., CHU, C.-H., HSU, C.-H., HSIEH, P.-C., CHUNG, T.-C., BAI, C.-H., YOU, S.-L., HWANG, L.-C., LIN, C.-M. and SUN, C.-A. (2012), Impact of metabolic syndrome on the incidence of chronic kidney disease: A Chinese cohort study. Nephrology, 17: 532–538. doi: 10.1111/j.1440-1797.2012.01607.x
- Issue published online: 23 JUL 2012
- Article first published online: 23 JUL 2012
- Accepted manuscript online: 4 APR 2012 11:39PM EST
- Accepted for publication 26 March 2012.; Accepted manuscript online 4 April 2012.
- chronic kidney disease;
- cohort study;
- metabolic syndrome;
Aim: Metabolic syndrome (MetS) is a major culprit in cardiovascular disease and chronic kidney disease (CKD) in Western populations. We studied the longitudinal association between MetS and incident CKD in Chinese adults.
Methods: A cohort study was conducted in a nationally representative sample of 4248 Chinese adults in Taiwan. The MetS was defined according to a unified criteria set by several major organizations and CKD was defined as an estimated glomerular filtration rate (eGFR) < 60 mL/min per 1.73 m2. Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) adjusted for sex, age, body mass index (BMI) and serum levels of total cholesterol.
Results: The prevalence of MetS among participants at baseline recruitment was 15.0% (637/4248). During a median follow-up period of 5.40 years, 208 subjects (4.9%) developed CKD. The multivariate-adjusted HR of CKD in participants with MetS compared with those without was 1.42 (95% CI = 1.03, 1.73). Additionally, there was a significantly graded relationship between the number of the MetS components and risk of CKD. Further, the relation between MetS and incident CKD was more robust in subjects with BMI >27.5 kg/m2 than in those with lower BMI.
Conclusion: The results suggest that the presence of MetS was significantly associated with increased risk of incident CKD in a Chinese population. These findings warrant future studies to test the impact of preventing and treating MetS on the reduction of the occurrence of CKD.