Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease


  • We thank Dr Motohiro Takeya for his editorial advice and Mr Toshiyuki Hisano for his excellent technical assistance.

Department of Neuropsychiatry, Kumamoto University School of Medicine, Honjo 1-1-1, Kumamoto 860, Japan.


Abstract It has been shown that human monocytes express monocyte chemoattractant protein-1 (MCP-1), an inflammatry factor, in response to non-fibrillar β-amyloid protein. Reactive microglia and inflammatory factors were reported to be present in β-amyloid deposits (senile plaques) in Alzheimer's disease, suggesting the presence of MCP-1 in senile plaques. To address this issue, we examined MCP-1-immunoreactivity in senile plaques using a mouse monoclonal anti-MCP-1 antibody. Monocyte chemoattractant protein-1 was found immunohistochemically in mature senile plaques and reactive microglia but not in immature senile plaques of brain tissues from five patients with Alzheimer's disease. These findings suggest that MCP-1-related inflammatory events induced by reactive microglia contribute to the maturation of senile plaques.