Effect of the combination of naltrexone and acamprosate on alcohol intake in mice
Article first published online: 17 DEC 2003
Psychiatry and Clinical Neurosciences
Volume 58, Issue 1, pages 30–36, February 2004
How to Cite
KIM, S.-G., HAN, B.-D., PARK, J.-M., KIM, M.-J. and STROMBERG, M. F. (2004), Effect of the combination of naltrexone and acamprosate on alcohol intake in mice. Psychiatry and Clinical Neurosciences, 58: 30–36. doi: 10.1111/j.1440-1819.2004.01189.x
- Issue published online: 17 DEC 2003
- Article first published online: 17 DEC 2003
- Received 14 April 2003; revised 16 June 2003; accepted 22 June 2003.
- alcohol intake;
- C57BL/6 mice;
Abstract Both naltrexone and acamprosate have been utilized clinically in recovering alcoholics with varying success. In the experiment reported here the combination of naltrexone and acamprosate was examined in a limited access alcohol model using C57BL/6 mice to determine if there was evidence of additive or synergistic effects. The results of this experiment demonstrate that naltrexone, at the higher dose but not the lower dose, significantly reduced alcohol consumption. When combined with naltrexone, acamprosate reduced alcohol consumption across both doses of naltrexone. This effect was sensitive to both dose and number of days of exposure to the naltrexone/acamprosate combination.