Reduced intracellular pH in the basal ganglia and whole brain measured by 31P-MRS in bipolar disorder
Version of Record online: 17 DEC 2003
Psychiatry and Clinical Neurosciences
Volume 58, Issue 1, pages 82–88, February 2004
How to Cite
HAMAKAWA, H., MURASHITA, J., YAMADA, N., INUBUSHI, T., KATO, N. and KATO, T. (2004), Reduced intracellular pH in the basal ganglia and whole brain measured by 31P-MRS in bipolar disorder. Psychiatry and Clinical Neurosciences, 58: 82–88. doi: 10.1111/j.1440-1819.2004.01197.x
- Issue online: 17 DEC 2003
- Version of Record online: 17 DEC 2003
- Received 17 July 2003; revised 26 August 2003; accepted 31 August 2003.
- basal ganglia;
- bipolar disorder;
- energy metabolism;
- intracellular pH;
- phosphorus magnetic resonance spectroscopy
Abstract The authors have previously reported that intracellular pH measured by phosphorus-31 magnetic resonance spectroscopy (31P-MRS) was decreased in the frontal lobes of patients with bipolar disorder. In the present study, phosphorus metabolism in the basal ganglia was examined in 13 patients with bipolar disorder and 10 matched controls by localized 31P-MRS. While no significant alteration of peak area ratios was found for all phosphorus metabolites, intracellular pH was significantly reduced in the basal ganglia in patients with bipolar disorder (7.014 ± 0.045) compared with control subjects (7.066 ± 0.047, P < 0.05). Unexpectedly, non-localized 31P-MR spectra also showed significantly lower levels of intracellular pH (6.970 ± 0.025) than controls (6.986 ± 0.024, P < 0.05). These results suggest that decreased intracellular pH in the brain of patients with bipolar disorder is not caused by dysfunction of the frontal lobes but reflect altered metabolism at the cellular level.