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Effectiveness of herbal medicine (Rokumigan and Hachimijiogan) for fatigue or loss of energy in patients with partial remitted major depressive disorder

  1. KAZUO YAMADA md , phd1,*,
  2. GOHEI YAGI md , phd2,
  3. SHIGENOBU KANBA md , phd3

Article first published online: 30 SEP 2005

DOI: 10.1111/j.1440-1819.2005.01423.x

Issue

Psychiatry and Clinical Neurosciences

Psychiatry and Clinical Neurosciences

Volume 59, Issue 5, pages 610–612, October 2005

Additional Information

How to Cite

YAMADA, K., YAGI, G. and KANBA, S. (2005), Effectiveness of herbal medicine (Rokumigan and Hachimijiogan) for fatigue or loss of energy in patients with partial remitted major depressive disorder. Psychiatry and Clinical Neurosciences, 59: 610–612. doi: 10.1111/j.1440-1819.2005.01423.x

Author Information

  1. 1

    Department of Psychiatry, Tokyo Women's Medical University, Tokyo

  2. 2

    Department of Neuropsychiatry, Keio University School of Medicine, Tokyo

  3. 3

    Department of Neuropsychiatry, Kyushu University, Graduate School of Medical Science, Fukuoka, Japan

*Dr Kazuo Yamada, Department of Psychiatry,  Tokyo Women's Medical University, Medical Center East, 2-1-10 Nishi-ogu, Arakawa-ku, Tokyo 116-8567, Japan. Email: yamadaps@dnh.twmu.ac.jp

Publication History

  1. Issue published online: 30 SEP 2005
  2. Article first published online: 30 SEP 2005
  3. Received 21 September 2004; revised 23 March 2005; accepted 3 April 2005.

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Keywords:

  • Hachimijiogan;
  • major depressive disorder;
  • partial remission;
  • Rokumigan;
  • Shofuku-fujin

Abstract  Some patients with major depressive disorder (MDD) do not show remission of their depressive symptomatology. We investigated the efficacy of Rokumigan (TJ-87) and Hachimijiogan (TJ-7) in 20 patients with prolonged partial remitted MDD associated with fatigue or loss of energy. In these 20 patients, TJ-7 or TJ-87 was added to the previous regimen for 4 weeks. Six patients were ‘much improved’, six were ‘minimally improved’ (responders), and eight showed ‘no change’ (non-responders), on the Clinical Global Impression Global Improvement scale. All responders had Shofuku-fujin (tenderness or weakness of the lower abdomen). In conclusion, we experienced 12 outpatients with prolonged partial remitted MDD with fatigue or loss of energy, which was successfully treated with TJ-87 or TJ-7.

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